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Figures 2 and 3 show forest plots and test statistics for the main outcomes, depression and anxiety, respectively, and subgroup analyses are shown in Supplementary data, Figs SII–SVII (online supplement).
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Mutations in genes that are directly coupled to control of thyroid cell cAMP, an intracellular second messenger that regulates growth, have also been identified.
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In clinical terms this represents the difference between, on average, mild depression in the PCOS groups and no depression in the control groups.
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