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In one embodiment, the lisinopril oral liquid formulation described herein is prepared by dissolving the buffer, the preservative, lisinopril, and the sweetener in water and adjusting the pH as needed with sodium hydroxide or hydrochloric acid. Because of the potential to contaminate urine with bacteria and cells from the surrounding skin during collection (particularly in women), it is important to first clean the genital area. The risk did not vary substantially by age (5–100 years) in the clinical trials analyzed.
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Em estudos de 18 meses, em ratos e camundongos, empregando-se doses de até 150 mg/kg/dia, não houve evidência de toxicidade significante induzida pela droga.   The FDA again refused the application, citing an uncertain risk/benefit ratio.
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